1254 Examining the Role of PET-CT in the Management of Oesophageal Cancer: A Single Institution Experience

Abstract Aim The role of PET-CT in oesophageal cancer is controversial. aim this study was to evaluate the utility staging and response evaluation squamous cell carcinoma (SCC) adenocarcinoma (AC). Method Patients undergoing curative-intent treatment were studied prospectively. PET1 carried out at diagnosis repeat scanning (PET2) performed 2-4 weeks post-completion neoadjuvant chemotherapy (nCT) or chemoradiation (nCRT). association between PET parameters, histopathologic survival determined using univariable multivariable regression models. Results 730 consecutive patients studied. identified CT-occult M1 disease 2.9% synchronous neoplasm 1.4%. Similar SUVmax values observed AC SCC. reduction greater post-nCRT versus nCT (P = 0.021). correlated with pT stage among treated primary surgery (P<0.001), however 32.3% 15.8% SCC who predicted node negative pN+. Post therapy, parameters showed modest associations major pathologic response, but no parameter accurately complete response. Among a metabolic (mCR), 90.9% post-nCT, 84.1% 54.8% had residual disease. Lower preoperative independently associated improved outcomes AC, not Conclusions neoplasms 4.3% initial staging. After poorly predictive – most an mCR have Nonetheless, improvements may reflect more favourable long-term outcome AC.